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[Coadministration of sorafenib and cisplatin inhibits proliferation of hepatocellular carcinoma HepG2 cells in vitro].

Authors
  • Chen, Feng-sheng
  • Cui, Yan-zhi
  • Luo, Rong-cheng
  • Wu, Jing
  • Zhang, Hua
Type
Published Article
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Publication Date
Aug 01, 2008
Volume
28
Issue
9
Pages
1684–1687
Identifiers
PMID: 18819900
Source
Medline
License
Unknown

Abstract

Sorafenib and DDP show a synergistic effect in inhibiting the proliferation and inducing apoptosis of HepG2 cells. The mechanisms of this synergistic effect can be closely related to the double blockage of the cell cycle and Raf/MEK/ERK pathway inhibition.

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