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Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.

Authors
  • Pan, Zhi-Zhong
  • Wan, De-Sen
  • Chen, Gong
  • Li, Li-Ren
  • Lu, Zhen-Hai
  • Huang, Bi-Jun
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Dec 15, 2004
Volume
10
Issue
24
Pages
3688–3690
Identifiers
PMID: 15534934
Source
Medline
License
Unknown

Abstract

IHC has a certain false positive and false negative rate in detecting p53 gene mutations. Malignant biological behaviours of rectal cancer are not enhanced by p53 and K-ras gene mutations. Co-mutation of p53 and K-ras gene has neither synergic carcinogenesis-promoting effect, nor prognostic effect on rectal cancer.

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