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Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating.

Authors
Type
Published Article
Journal
Biotechnology Letters
1573-6776
Publisher
Springer-Verlag
Publication Date
Volume
33
Issue
6
Pages
1265–1268
Identifiers
DOI: 10.1007/s10529-011-0542-7
PMID: 21287232
Source
Medline
License
Unknown

Abstract

We have incorporated bisphosphonates and antibiotics simultaneously into a biomimetic hydroxyapatite implant coating aiming to use the interaction between drug-molecules and hydroxyapatite to enable local release of the two different substances to obtain a dual biological effect. A sustained release over for 43 h of antibiotics (cephalothin) was achieved without negative interference from the presence of the bisphosphonate (clodronate) which, in turn, successfully bonded to the coating surface. To our knowledge, this is the first study that indicates the possibility to simultaneously incorporate both antibiotics and bisphosphonates to an implant coating, a strategy that is believed to improve implant stability and reduce implant-related infections.

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