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CNS germinomas: what is the best treatment strategy?

Authors
  • 1
  • 1 Department of Radiation Oncology, The University of Texas Medical Branch, Trauma Center, 301 University Boulevard, Galveston, TX 77555-1178, USA. [email protected]
Type
Published Article
Journal
Expert Review of Neurotherapeutics
1744-8360
Publisher
Informa UK (Taylor & Francis)
Publication Date
Volume
8
Issue
10
Pages
1527–1536
Identifiers
DOI: 10.1586/14737175.8.10.1527
PMID: 18928345
Source
Medline
License
Unknown

Abstract

CNS germ cell tumors are rare primary brain malignancies. Germinomas comprise approximately two-thirds of CNS germ cell tumors. Owing to their radiosensitivity, radiotherapy has been used to treat patients with CNS germinomas, with favorable treatment outcomes. Historically, craniospinal irradiation has been used. Given the concerns over long-term toxicities associated with craniospinal irradiation, reduced volume radiotherapy with or without chemotherapy has been employed. Data on the use of different strategies in the treatment of CNS germinomas are emerging but a standard strategy has not been established. This article reviews the different strategies used in the management of CNS germinomas.

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