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A CMOS Electrochemical Impedance Spectroscopy (EIS) Biosensor Array.

Authors
  • Manickam, Arun
  • Chevalier, Aaron
  • McDermott, Mark
  • Ellington, Andrew D
  • Hassibi, Arjang
Type
Published Article
Journal
IEEE transactions on biomedical circuits and systems
Publication Date
Dec 01, 2010
Volume
4
Issue
6
Pages
379–390
Identifiers
DOI: 10.1109/TBCAS.2010.2081669
PMID: 23850755
Source
Medline
License
Unknown

Abstract

In this paper, we present a fully integrated biosensor 10 × 10 array in a standard complementary metal-oxide semiconducor process, which takes advantage of electrochemical impedance spectroscopy (EIS). We also show that this system is able to detect various biological analytes, such as DNA and proteins, in real time and without the need for molecular labels. In each pixel of this array, we implement a biocompatible Au electrode transducer and embedded sensor circuitry which takes advantage of the coherent detector to measure the impedance of the associated electrode-electrolyte interface. This chip is capable of concurrently measuring admittance values as small as 10(-8) Ω(-1) within the array with the detection dynamic range of more than 90 dB in the frequency range of 10 Hz-50 MHz.

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