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clpP of Streptococcus salivarius Is a Novel Member of the Dually Regulated Class of Stress Response Genes in Gram-Positive Bacteria

Authors
  • Arnaud Chastanet
  • Tarek Msadek
Publisher
American Society for Microbiology
Publication Date
Jan 01, 2003
Source
PMC
Keywords
License
Unknown

Abstract

Nucleotide sequence analysis of the Streptococcus salivarius clpP locus revealed potential binding sites for both the CtsR and HrcA repressors. Dual regulation by HrcA and CtsR was demonstrated by using Bacillus subtilis as a heterologous host, and CtsR was shown to bind directly to the clpP promoter sequence. This is the first example of a clpP gene under the control of HrcA.

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