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The SEACIT complex is involved in the maintenance of vacuole–mitochondria contact sites and controls mitophagy

Authors
  • Ma, Yinxing1
  • Moors, Alexis1
  • Camougrand, Nadine2, 3
  • Dokudovskaya, Svetlana1
  • 1 CNRS, UMR 8126, Université Paris-Sud 11, Institut Gustave Roussy, 114, rue Edouard Vaillant, Villejuif, 94805, France , Villejuif (France)
  • 2 CNRS, IBGC, UMR 5095, 1, rue Camille Saint-Saens, Bordeaux, 33000, France , Bordeaux (France)
  • 3 Université de Bordeaux, IBGC, 1, rue Camille Saint-Saens, Bordeaux, 33000, France , Bordeaux (France)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Jan 23, 2019
Volume
76
Issue
8
Pages
1623–1640
Identifiers
DOI: 10.1007/s00018-019-03015-6
Source
Springer Nature
Keywords
License
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Abstract

The major signaling pathway that regulates cell growth and metabolism is under the control of the target of rapamycin complex 1 (TORC1). In Saccharomyces cerevisiae the SEA complex is one of the TORC1 upstream regulators involved in amino acid sensing and autophagy. Here, we performed analysis of the expression, interactions and localization of SEA complex proteins under different conditions, varying parameters such as sugar source, nitrogen availability and growth phase. Our results show that the SEA complex promotes mitochondria degradation either by mitophagy or by general autophagy. In addition, the SEACIT subcomplex is involved in the maintenance of the vacuole–mitochondria contact sites. Thus, the SEA complex appears to be an important link between the TORC1 pathway and regulation of mitochondria quality control.

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