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Close linkage of human chromosomal pepsinogen A genes.

Authors
  • Hayano, T
  • Sogawa, K
  • Ichihara, Y
  • Fujii-Kuriyama, Y
  • Takahashi, K
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Jul 16, 1986
Volume
138
Issue
1
Pages
289–296
Identifiers
PMID: 3017318
Source
Medline
License
Unknown

Abstract

We have obtained a clone containing two pepsinogen A genes in a single insert by screening a recombinant cosmid library for human genomic DNA. Restriction endonuclease mappings of this cloned DNA showed that these two genes are very similar, but distinct in structure, and that they are closely linked to one another in the human chromosome DNA. The close arrangement of the genes with very similar structures could facilitate the homologous recombination or the unequal crossing-over which accounts for high frequency of haplotype variation in copy number of pepsinogen A genes as reported by Taggart et al.

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