Affordable Access

Clopidogrel: an updated and comprehensive review.

Authors
  • Fox, Keith A A
  • Chelliah, Raj
Type
Published Article
Journal
Expert opinion on drug metabolism & toxicology
Publication Date
Aug 01, 2007
Volume
3
Issue
4
Pages
621–631
Identifiers
PMID: 17696811
Source
Medline
License
Unknown

Abstract

The risk of adverse events in patients with acute coronary syndrome remains substantial despite the use of regular aspirin. The addition of clopidogrel to regular aspirin therapy has been shown to be associated with significantly better outcomes in a variety of clinical settings within the spectrum of acute coronary syndromes. In this article, the evidence and therapeutic implications for the use of clopidogrel in patients with non-ST-elevation and ST elevation acute coronary syndromes is discussed, and also in those undergoing percutaneous coronary intervention. The use of clopidogrel in combination with other antithrombotics in the acute setting is considered, including glycoprotein IIb/IIIa receptor antagonists and direct thrombin inhibitors. Clopidogrel has changed the way in which patients with non-ST-elevation and, more recently, ST elevation acute coronary syndromes are treated.

Report this publication

Statistics

Seen <100 times