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Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway.

Authors
  • Rosa, R G1
  • Collavino, K2
  • Lakhani, A3
  • Delve, E4
  • Weber, J F5
  • Rosenthal, A K6
  • Waldman, S D7
  • 1 Human Mobility Research Centre, Kingston General Hospital, Kingston, Ontario, Canada. Electronic address: [email protected] , (Canada)
  • 2 Department of Chemical Engineering, Ryerson University, Toronto, Ontario, Canada; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address: [email protected] , (Canada)
  • 3 Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada. Electronic address: [email protected] , (Canada)
  • 4 Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada. Electronic address: [email protected] , (Canada)
  • 5 Department of Mechanical & Materials Engineering, Queen's University, Kingston, Ontario, Canada. Electronic address: [email protected] , (Canada)
  • 6 Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, and the Zablocki VA Medical Center, Milwaukee, WI, USA. Electronic address: [email protected]
  • 7 Department of Chemical Engineering, Ryerson University, Toronto, Ontario, Canada; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier
Publication Date
September 2014
Volume
22
Issue
9
Pages
1327–1336
Identifiers
DOI: 10.1016/j.joca.2014.07.009
PMID: 25042551
Source
Medline
Keywords
License
Unknown

Abstract

These findings support the previous notion that certain bisphosphonates may be useful as adjunctive therapies to potentially ameliorate progression of cartilage degeneration and improve arthritis management.

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