Affordable Access

[Clinico-pharmacological evaluation of omeprazole, as a proton pump inhibitor, compared with H2-blockers].

Authors
  • Nakashima, M
  • Kanamaru, M
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Jan 01, 1992
Volume
50
Issue
1
Pages
60–67
Identifiers
PMID: 1347331
Source
Medline
License
Unknown

Abstract

We evaluated the safety, tolerance, pharmacokinetics and pharmacodynamics of omeprazole, a new anti-ulcer agent chiefly on the basis of our studies in healthy male volunteers. The type and incidence of side effects of omeprazole have been reported to be similar to those of H2-antagonists, and in our studies too, omeprazole was estimated to be safe and tolerable. Following single doses, the increase in AUC was not proportional to the increase in dosage. In the multiple-dose study, the AUC was greater on day 7 than on day 1. This finding may be due to a partial saturation of first pass elimination. Repeated omeprazole treatment (20 mg once daily for 4 days) inhibited the basal and stimulated acid secretion. Though H2-blockers inhibit the basal and stimulated pepsin secretion, omeprazole inhibited the stimulated pepsin secretion only.

Report this publication

Statistics

Seen <100 times