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Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder.

Authors
  • Bangerter, Abigail1
  • Ness, Seth2
  • Lewin, David2, 3
  • Aman, Michael G4
  • Esbensen, Anna J5
  • Goodwin, Matthew S6
  • Dawson, Geraldine7
  • Hendren, Robert8, 9
  • Leventhal, Bennett8, 9
  • Shic, Fred10, 11, 12
  • Opler, Mark13
  • Ho, Kai Fai14
  • Pandina, Gahan2
  • 1 Department of Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, USA. [email protected]
  • 2 Department of Neuroscience, Janssen Research & Development, LLC, Titusville, NJ, USA.
  • 3 Statistically Speaking Consulting, LLC, Chicago, IL, USA.
  • 4 Department of Psychology, Ohio State University, 175C McCampbell, 1581 Dodd Drive, Columbus, OH, USA.
  • 5 Division of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, 3430 Burnet Avenue, ML 4002, Cincinnati, OH, USA.
  • 6 Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, 312E Robinson Hall, 360 Huntington Avenue, Boston, MA, USA.
  • 7 Duke Center for Autism and Brain Development, Duke University, 2608 Erwin Road, Suite 300, Durham, NC, USA.
  • 8 Department of Psychiatry and the Weill Institute for Neuroscience, University of California, San Francisco, 401 Parnassus Ave, San Francisco, CA, USA.
  • 9 Benioff Children's Hospital, University of California, San Francisco,, San Francisco, CA, USA.
  • 10 Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
  • 11 Department of Pediatrics, University of Washington, Seattle, WA, USA.
  • 12 Yale Child Study Center, Hartford, CT, USA.
  • 13 MedAvante-ProPhase, Inc, NYU School of Medicine, 3 Park Avenue Floors 28, 37, New York, NY, USA.
  • 14 STAT-TU Inc, Toronto, Canada. , (Canada)
Type
Published Article
Journal
Journal of Autism and Developmental Disorders
Publisher
Springer-Verlag
Publication Date
Jun 01, 2020
Volume
50
Issue
6
Pages
2090–2101
Identifiers
DOI: 10.1007/s10803-019-03965-7
PMID: 30888551
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confirmed diagnoses of ASD (N = 144) completed the ABI and other rating scales at 4 time points. Scale consistency for each domain, 3-5 day test-retest reliability, and construct validity, determined by comparison to pre-specified scales, were all good. Change in the ABI was congruent with changes in other instruments. Collectively, results suggest incipient suitability of the ABI as a measure of changes in core and associated symptoms of ASD.Trial Registration NCT02299700.

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