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The clinical utility of a novel blood-based multi-transcriptome assay for the diagnosis of neuroendocrine tumors of the gastrointestinal tract.

Authors
  • Modlin, I M1
  • Kidd, M2
  • Bodei, L3
  • Drozdov, I2
  • Aslanian, H4
  • 1 1] Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA [2] Wren Laboratories, Branford, Connecticut, USA.
  • 2 Wren Laboratories, Branford, Connecticut, USA.
  • 3 Division of Nuclear Medicine, European Institute of Oncology (IEO), Milan, Italy. , (Italy)
  • 4 Section of Digestive Diseases, Yale University, New Haven, Connecticut, USA.
Type
Published Article
Journal
The American Journal of Gastroenterology
Publisher
Springer Nature
Publication Date
Aug 01, 2015
Volume
110
Issue
8
Pages
1223–1232
Identifiers
DOI: 10.1038/ajg.2015.160
PMID: 26032155
Source
Medline
License
Unknown

Abstract

This study demonstrates that a blood-based multianalyte NET gene transcript measurement of well-differentiated small intestinal and pancreatic neuroendocrine tumor disease is sensitive and specific and outperforms the current monoanalyte diagnostic strategy of plasma CgA measurement.

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