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Clinical Trials Using LV-P140K-MGMT for Gliomas

Authors
  • Lin, Yuan
  • Gerson, Stanton L.
Type
Book
Journal
Gene Therapy of Cancer
Publication Date
Jan 01, 2014
Pages
379–391
Identifiers
DOI: 10.1016/B978-0-12-394295-1.00026-3
ISBN: 978-0-12-394295-1
Source
Elsevier
Keywords
License
Unknown

Abstract

The field of gene therapy has experienced some success in the past decade. However, overall, gene therapy clinical trials have been challenging due to low transduction efficiency and low transgene expression. To overcome these obstacles, drug-resistance gene therapy provides an alternative to enrich gene-modified cells and enhance transgene expression. In this chapter, we present an overview of current gene-resistance gene therapy and different mechanisms of drug resistance that have been used in the selection of gene-modified cells. Although the first clinical applications are concentrated in cancer applications, the technology may be widely applicable. Finally, we also describe using this technique for the treatment of human gliomas.

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