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Clinical screening of gene rearrangements in childhood leukemia by using a multiplex polymerase chain reaction-microarray approach.

Authors
  • Nasedkina, Tatyana V
  • Zharinov, Vladislav S
  • Isaeva, Ekaterina A
  • Mityaeva, Olga N
  • Yurasov, Roman N
  • Surzhikov, Sergei A
  • Turigin, Alexander Y
  • Rubina, Alla Y
  • Karachunskii, Alexander I
  • Gartenhaus, Ronald B
  • Mirzabekov, Andrei D
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Nov 15, 2003
Volume
9
Issue
15
Pages
5620–5629
Identifiers
PMID: 14654544
Source
Medline
License
Unknown

Abstract

Our data suggest that the microarray-based assay can be an effective and reliable tool in the clinical screening of leukemia patients for the presence of specific gene rearrangements with important diagnostic and prognostic implications. The method is amenable for automation and high-throughput analysis.

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