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The clinical role of natriuretic peptides--importance of BNP and NT-proBNP. Implications in heart failure and acute coronary syndrome.

Authors
Type
Published Article
Journal
Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
Publication Date
Volume
23
Issue
7-8
Pages
1005–1032
Identifiers
PMID: 15478326
Source
Medline

Abstract

Natriuretic peptides are increasingly used as biomarkers for several clinical entities. An overview of the clinical applications of brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) is presented. These neurohormones are used for diagnosis, monitoring and predicting prognosis in patients with chronic heart failure. The indications extend to risk stratification and prognosis of acute coronary syndromes and prognosis of acute pulmonary embolism. An appraisal of the influence of beta-blockers and other drugs in the measurement of natriuretic peptides is performed. The clinical effectiveness of treatment with the cardiac hormone nesiritide (human B-type natriuretic peptide) in heart failure is assessed.

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