The present study analyzes a 7-year experience of two concurrent groups of patients, one with and one without coronary artery disease. These groups underwent aortic valve replacement within the same time frame. They had the same method of myocardial protection and type of valve substitute, and there was no postoperative anticoagulant therapy. There was no statistically significant difference in hospital and late mortality, or in actuarial survival of the two groups after 4 years. Bypass grafting in patients with coronary artery disease undergoing aortic valve replacement reverts these groups of patients to the longterm prognostic level of patients with isolated aortic valve disease undergoing aortic valve replacement.