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Clinical outcome of triple negative breast cancer in BRCA1 mutation carriers and noncarriers.

Authors
  • Lee, Larissa J
  • Alexander, Brian
  • Schnitt, Stuart J
  • Comander, Amy
  • Gallagher, Bridget
  • Garber, Judy E
  • Tung, Nadine
Type
Published Article
Journal
Cancer
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 15, 2011
Volume
117
Issue
14
Pages
3093–3100
Identifiers
DOI: 10.1002/cncr.25911
PMID: 21264845
Source
Medline
License
Unknown

Abstract

BRCA1 mutation carriers with TN disease had similar survival rates to noncarriers when treated with alkylating chemotherapy. Women with BRCA1-related breast cancer may benefit from novel therapies that target DNA repair, and further study is needed to identify sporadic TN breast cancers with a BRCA-deficient phenotype.

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