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Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain.

Authors
  • Pérez-Martinez, Antonio1
  • Guerra-García, Pilar1
  • Melgosa, Marta2
  • Frauca, Esteban3
  • Fernandez-Camblor, Carlota2
  • Remesal, Agustin4
  • Calvo, Cristina5, 6
  • 1 Pediatric Hemato-Oncology Department, Hospital Universitario La Paz, Madrid, Spain. , (Spain)
  • 2 Pediatric Nephrology Department, Hospital Universitario La Paz, Madrid, Spain. , (Spain)
  • 3 Pediatric Hepatology Department, Hospital Universitario La Paz, Madrid, Spain. , (Spain)
  • 4 Pediatric Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain. , (Spain)
  • 5 Pediatric and Infectious Diseases Department, Hospital Universitario La Paz, Paseo de la Castellana, 261 28046, Madrid, Spain. [email protected] , (Spain)
  • 6 Fundación IdiPaz, Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain. [email protected] , (Spain)
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
Mar 01, 2021
Volume
180
Issue
3
Pages
967–971
Identifiers
DOI: 10.1007/s00431-020-03793-3
PMID: 32860101
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases. A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed. In this series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital. The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy. The rational and prudent management of these patients is discussed, evaluating possible treatments and options for hospitalization or outpatient follow-up.Conclusion: In our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients if close monitoring is possible. Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress are present. What is Known: • SARS-CoV-2 infection is usually mild in children. What is New: • Outcome of immunosuppressed children with COVID-19 is generally good, with a mild-moderate course.

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