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[Clinical observation on efficacy of ivermectin in the treatment of intestinal nematode infections].

Authors
  • Xia, Z H
  • Su, Y L
  • Yao, S Y
  • Shen, B R
  • Wen, L Y
  • Song, C C
  • Wu, Z K
  • Zou, Y C
  • Meng, J C
  • Yang, H L
Type
Published Article
Journal
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases
Publication Date
Jan 01, 1992
Volume
10
Issue
4
Pages
279–282
Identifiers
PMID: 1303336
Source
Medline
License
Unknown

Abstract

A total of 166 cases were divided into 3 groups: group A comprised 55, group B 54 and group C 57 cases. Group A received ivermectin 0.1 mg/kg orally at a single dose, the cure rates were 100%, 3.8% and 50% for ascaris, hookworm and trichuris, infections respectively: group B received ivermectin 0.2 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 11.8% and 76.5% respectively; group C received pyrantel pamoate 10 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 29.6% and 31.6% respectively. Although the cure rates were very low for hookworm infection in both group A and B, however, a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm. Side effects were mild and transient in all groups.

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