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Clinical and Neuroimaging Characteristics in Embolic Stroke of Undetermined versus Cardioembolic Origin: A Population-Based Study.

Authors
  • Tsivgoulis, Georgios1, 2
  • Kargiotis, Odysseas3
  • Katsanos, Aristeidis H2, 4
  • Patousi, Athanasia1
  • Pikilidou, Maria5
  • Birbilis, Theodosis6
  • Mantatzis, Michael7
  • Palaiodimou, Lina2
  • Triantafyllou, Sokratis2
  • Papanas, Nikolaos8
  • Skendros, Panagiotis9
  • Terzoudi, Aikaterini1
  • Georgiadis, George S10
  • Maltezos, Efstratios8
  • Piperidou, Charitomeni1
  • Serdari, Aspasia11
  • Theodorou, Aikaterini2
  • Ikonomidis, Ignatios12
  • Heliopoulos, Ioannis1
  • Vadikolias, Konstantinos1
  • 1 Department of Neurology, University Hospital of Alexandroupolis, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 2 Second Department of Neurology, "Attikon" University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece. , (Greece)
  • 3 Stroke Unit, Metropolitan Hospital, Piraeus, Greece. , (Greece)
  • 4 Department of Neurology, University of Ioannina, School of Medicine, Ioannina, Greece. , (Greece)
  • 5 Excellence Center, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. , (Greece)
  • 6 Department of Neurosurgery, University Hospital of Alexandroupolis, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 7 Department of Radiology, University Hospital of Alexandroupolis, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 8 Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 9 First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 10 Department of Vascular Surgery, Democritus University of Thrace, School of Medicine, Alexandroupolis, Greece. , (Greece)
  • 11 Department of Child and Adolescent Psychiatry, Democritus University of Thrace, University Hospital of Alexandroupolis.
  • 12 Second Department of Cardiology, "Attikon" University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. , (Greece)
Type
Published Article
Journal
Journal of Neuroimaging
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2019
Volume
29
Issue
6
Pages
737–742
Identifiers
DOI: 10.1111/jon.12660
PMID: 31463999
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Evidence suggests that cardioembolism represents the underlying mechanism in the minority of embolic strokes of undetermined source (ESUS). In this population-based study, we sought to compare the clinical and imaging characteristics as well as outcomes in patients with ESUS and cardioembolic stroke (CE). We included consecutive patients with first-ever ischemic stroke (IS) from the previously published population-based Evros-Stroke-Registry identified as ESUS or CE according to standardized criteria. Baseline characteristics, admission NIHSS scores, cerebral edema, hemorrhagic transformation, stroke recurrence, functional outcomes (determined by modified Rankin Scale [mRS] scores), and mortality rates were recorded during the 1-year follow-up period. We identified 21 ESUS (3.7% of IS) and 211 CE (37.1% of IS) cases. Patients with ESUS were younger (median age: 68 years [interquartile range [IQR]: 61-75] vs 80 years [IQR: 75-84]; P < .001), had lower median admission NIHSS scores (4 points [IQR: 2-8] vs 10 points [IQR: 5-17]; P < .001), and lower prevalence of cerebral edema on neuroimaging studies (0 vs. 33.3%, P = .002). Functional outcomes were more favorable in ESUS at 28 (median mRS score: 2 [IQR: 1-3] vs 4 [IQR: 4-5]; P < .001), 90 (median mRS score: 1 [IQR: 0-2] vs 4 [IQR: 3-5]; P < .001), and 365 days (median mRS score: 1 [IQR: 0-2] vs 4 [IQR: 2-4]; P < 0.001). At 1-year, the mortality rate was lower in ESUS (0% [95% confidence interval [CI]: 0-13.5%] vs 34.6% [95% CI: 28.2-41.0%]; P < .001); the 1-year recurrent rate was also lower numerically (0% [95% CI: 0-13.5%] vs 9.5% [95% CI: 5.5-13.4%]; P = .140) but this difference failed to reach statistical significance due to the small study population. The clinical and neuroimaging profiles as well as clinical outcomes vary substantially between ESUS and CE indicating different underlying mechanisms. © 2019 by the American Society of Neuroimaging.

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