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Clinical and molecular analysis of chinese patients with thyrotoxic periodic paralysis.

Authors
Type
Published Article
Journal
European Neurology
0014-3022
Publisher
S. Karger AG
Publication Date
Volume
49
Issue
4
Pages
227–230
Identifiers
PMID: 12736539
Source
Medline

Abstract

Although sporadic thyrotoxic periodic paralysis (TPP) has a much higher prevalence in Asian than in all the other populations studied so far, it is also increasingly being seen at the emergency departments of the West, hence, it is vital to stress the importance of recognizing it. TPP shares some similarities with hypokalemic periodic paralysis (HOKPP). However, the pathophysiology of TPP and the reasons for this higher incidence are not known. We hypothesized that some mutations in the CACNA1S gene, which has been implicated in familial HOKPP, might play a role in TPP. We present 5 Chinese patients who suffer from TPP and demonstrate typical clinical features. No mutation was found on the whole CACNA1S gene. Therefore other molecular mechanisms will have to be examined in order to explain the different TPP incidences.

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