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Clinical and mechanistic drivers of acute traumatic coagulopathy.

Authors
  • Cohen, Mitchell Jay
  • Kutcher, Matt
  • Redick, Britt
  • Nelson, Mary
  • Call, Mariah
  • Knudson, M Margaret
  • Schreiber, Martin A
  • Bulger, Eileen M
  • Muskat, Peter
  • Alarcon, Louis H
  • Myers, John G
  • Rahbar, Mohammad H
  • Brasel, Karen J
  • Phelan, Herb A
  • del Junco, Deborah J
  • Fox, Erin E
  • Wade, Charles E
  • Holcomb, John B
  • Cotton, Bryan A
  • Matijevic, Nena
  • And 1 more
Type
Published Article
Journal
The journal of trauma and acute care surgery
Publication Date
Jul 01, 2013
Volume
75
Issue
1 Suppl 1
Identifiers
DOI: 10.1097/TA.0b013e31828fa43d
PMID: 23778510
Source
Medline
License
Unknown

Abstract

ATC is associated with the depletion of factors I, II, V, VII, VIII, IX, and X and is driven by the activation of the protein C system. These data provide additional mechanistic understanding of the drivers of coagulation abnormalities after injury. Further understanding of the drivers of ATC and the effects of resuscitation can guide factor-guided resuscitation and correction of coagulopathy after injury.

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