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Clinical implications of 18F-sodium fluoride uptake in subclinical aortic valve calcification: Its relation to coronary atherosclerosis and its predictive value.

Authors
  • Nakamoto, Yumiko1
  • Kitagawa, Toshiro2
  • Sasaki, Ko3
  • Tatsugami, Fuminari4
  • Awai, Kazuo4
  • Hirokawa, Yutaka3
  • Kihara, Yasuki1
  • 1 Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. , (Japan)
  • 2 Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. [email protected] , (Japan)
  • 3 Hiroshima Heiwa Clinic, Hiroshima, Japan. , (Japan)
  • 4 Department of Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Japan. , (Japan)
Type
Published Article
Journal
Journal of Nuclear Cardiology
Publisher
Springer-Verlag
Publication Date
Aug 01, 2021
Volume
28
Issue
4
Pages
1522–1531
Identifiers
DOI: 10.1007/s12350-019-01879-6
PMID: 31482532
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Uptake of 18F-sodium fluoride (18F-NaF) on positron emission tomography (PET) reflects active calcification. Application of this technique in the early phase of aortic valve calcification (AVC) is of clinical interest. We investigated clinical implications of 18F-NaF uptake in subclinical AVC evaluated simultaneously with coronary atherosclerosis, and the utility of 18F-NaF uptake in predicting AVC progression. We studied 25 patients with subclinical AVC and coronary plaques detected on computed tomography (CT) who underwent 18F-NaF PET/CT. AVC score, volume, mean density, and the presence of high-risk coronary plaque were evaluated on CT in each patient. Focal 18F-NaF uptake in AVC and in coronary plaques was quantified with the maximum tissue-to-background ratio (TBRmax). There were positive correlations between AVC TBRmax (A-TBRmax) and AVC parameters on CT. The 14 patients with high-risk coronary plaque had significantly higher A-TBRmax than those without such plaque (1.60 ± 0.18 vs 1.42 ± 0.13, respectively; P = 0.012). A-TBRmax positively correlated with maximum TBRmax of coronary plaque per patient (r = 0.55, P = 0.0043). In the 11 patients who underwent follow-up CT scan, A-TBRmax positively correlated with subsequent increase in AVC score (r = 0.74, P = 0.0091). Our 18F-NaF PET- and CT-based data indicate relationships between calcification activity in subclinical AVC and characteristics of coronary atherosclerosis. 18F-NaF PET may provide new information regarding molecular conditions and future progression of subclinical AVC. © 2019. American Society of Nuclear Cardiology.

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