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Clinical and histopathologic study of varicella zoster virus retinitis in patients with the acquired immunodeficiency syndrome.

Authors
  • Kuppermann, B D
  • Quiceno, J I
  • Wiley, C
  • Hesselink, J
  • Hamilton, R
  • Keefe, K
  • Garcia, R
  • Freeman, W R
Type
Published Article
Journal
American Journal of Ophthalmology
Publisher
Elsevier
Publication Date
Nov 15, 1994
Volume
118
Issue
5
Pages
589–600
Identifiers
PMID: 7977572
Source
Medline
License
Unknown

Abstract

Varicella zoster virus retinitis in patients with the acquired immunodeficiency syndrome is known to be a devastating disease. We studied a series of six consecutive patients that sheds new light on the clinical manifestations and treatment options of this disorder. All patients had episodes of cutaneous zoster, long-term exposure to oral acyclovir, and CD4+ T lymphocyte counts less than 50 cells/mm3. Two of the six patients had simultaneous radiographically demonstrable and histologically proven varicella zoster virus encephalitis; this is an important association. Histologic examination of autopsy specimens disclosed that the retinal infection by varicella zoster virus involves the retinal pigment epithelium more heavily than the inner retina, which is consistent with the characteristic clinical impression of an outer retinal necrosis.

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