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Clinical and histological features and outcomes of upper eyelid colobomas in the Saudi population.

Authors
  • Al Essa, Dalal1, 2
  • Khandekar, Rajiv3
  • Galindo-Ferreiro, Alicia1, 4
  • Edward, Deepak P5, 6
  • Maktabi, Azza5
  • Al Hussein, Hailah1
  • Al Sheikh, Osama1
  • Strianese, Diego1
  • Schellini, Silvana A1
  • 1 Oculoplastic and Orbit Division, King Khaled Eye Specialist Hospital , Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 2 Department of Ophthalmology, College of Medicine, Imam Muhammad Ibn Saud Islamic University , Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 3 Department of Research, King Khaled Eye Specialist Hospital , Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 4 Department of Ophthalmology, Rio Hortega University Hospital , Valladolid, Spain. , (Spain)
  • 5 Pathology Division, King Khaled Eye Specialist Hospital , Riyadh, Saudi Arabia. , (Saudi Arabia)
  • 6 Department of Ophthalmology, University of Illinois Eye and Ear Infirmary , Chicago, Illinois, USA.
Type
Published Article
Journal
Orbit (Amsterdam, Netherlands)
Publication Date
Oct 01, 2020
Volume
39
Issue
5
Pages
325–330
Identifiers
DOI: 10.1080/01676830.2019.1690006
PMID: 31722593
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To study the clinical features, histopathology, and management of congenital upper eyelid coloboma (CEC) in the Saudi population. A retrospective review of health records evaluated the demographics, histopathology, and surgical outcomes of patients with CEC. Thirty-nine eyelids of 27 patients were included in this study. CEC was bilateral in 12 (44.4%) patients, isolated in 17 (62.9%), and as part of a syndrome in 10 (37.1%) patients. CEC was commonly located in the medial upper lid (22 lids, 56.4%) and mostly involved the full thickness of the lid (27 lids, 69.2%). Corneal adhesion (18 eyes, 46.1%) and poorly formed eyebrows (21 eyebrows, 53.8%) were the most common ocular/adnexa associations. Histopathology was similar in all cases and the main features were scarred dermis, atrophic orbicularis oculi, and atrophic or absent tarsus. Visual acuity at the final follow-up was 20/50 or better in 13 (33.3%) eyes. Complete lid closure without lagophthalmos after one or more surgical procedures was achieved in 11 (40.7%) cases. CEC features in Saudi patients are similar to those described in the literature. Dermal scarring and defective orbicularis muscles are common. Achieving cosmetic and functional success after management remains challenging.

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