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Clinical effects of selective thromboxane A2 synthetase inhibitor in patients with nephrotic syndrome.

Authors
  • Niwa, T
  • Maeda, K
  • Shibata, M
  • Yamada, K
Type
Published Article
Journal
Clinical Nephrology
Publisher
Dustri-Verlag Dr. Karl Feistle
Publication Date
Nov 01, 1988
Volume
30
Issue
5
Pages
276–281
Identifiers
PMID: 3214971
Source
Medline
License
Unknown

Abstract

To determine if a selective thromboxane (TX)A2 synthetase inhibitor is clinically effective for the treatment of nephrotic syndrome, 11 patients with nephrotic syndrome were treated only with OKY-046, (E)-3-4-(1-imidazolylmethyl)phenyl-2-propenoic acid hydrochloride monohydrate, for at least 8 weeks. Urinary excretion of protein, TXB2, 2,3-dinor-TXB2, and beta-N-acetyl-D-glucosaminidase decreased with OKY-046. Creatinine clearance value, and urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), however, did not show any significant change, while serum albumin level increased. Two patients with minimal change nephrotic syndrome showed complete remission only with OKY-046. These results demonstrate that the selective TXA2 synthetase inhibitor is an effective drug for the treatment of chronic glomerulonephritis accompanied by nephrotic syndrome.

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