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Clinical Characteristics and Outcome of Malignant Eyelid Tumors: A Five-Year Retrospective Study.

  • Burgic, Mufid1
  • Iljazovic, Ermina2
  • Vodencarevic, Amra Nadarevic3
  • Burgic, Musfaha1
  • Rifatbegovic, Adi1
  • Mujkanovic, Amer1
  • Halilbasic, Meliha4
  • Sinanovic, Mersiha4
  • 1 Clinic for Plastic and Maxillofacial surgery, University Clinical Center Tuzla, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 2 Clinic for Laboratory Diagnostics, Department of Pathology, University Clinical Center Tuzla, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 3 Health Center Tuzla, Department of Ophthalmology, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
  • 4 Clinic for Ophthalmology, University Clinical Center Tuzla, Bosnia and Herzegovina. , (Bosnia & Herzegovina)
Published Article
Medical archives (Sarajevo, Bosnia and Herzegovina)
Publication Date
Jun 01, 2019
DOI: 10.5455/medarh.2019.73.209-212
PMID: 31402806


To the best of our knowledge, this is the first study about malignant eyelid tumors in the region of Tuzla, Bosnia and Herzegovina, and it shows similar results comparing with other countries (the annual incidence of eyelid tumors in Tuzla region is about 3.73/100 000 population). Malignant eyelid tumors are relatively uncommon, but potentially fatal disease. However, if detected early and treated adequately, the prognosis is generally excellent. The aim of this study was the clinical and microscopical analysis of malignant eyelid tumors in treated patients, the presentation of surgical treatment and reconstructive methods of eyelid tumors. This retrospective study included 60 patients surgically treated at the University Clinical Center Tuzla from January 2012 to December 2016, who were initially diagnosed with malignant eyelid tumors in accordance to the final results obtained by histological examination of excised lesions. In the group of malignant tumors, the most common tumors were BCC (85%), which were predominantly found on the lower eyelids (92.16%) and showed female predominance (51.06%). SCC was the second most common eyelid malignancy (15%) and showed a predilection for the lower eyelid involvement and male predominance (55.56%). Tumors up to 2 cm in diameter (clinical stage T1) were found in 78.33% of cases, 95.74% of which with radical excision, while 4.26% with non-radical excision. Treatment by complete excision with histological confirmation of tumor clearance is recommended. Perineural spread is an adverse prognostic sign, which may require postoperative radiotherapy. Orbital invasion is a rare complication but, if recognized early, it can be treated effectively with exenteration. Because presentation varies and histological examination is required for accurate diagnosis, any suspicious lesion occurring on the eyelids should be excised or biopsied. All patients with malignant tumors should be advised of the risk of recurrent or new tumors and encouraged to attend lifelong follow up.

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