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[Clinical characteristics of emerging multiple-drug-resistant gram-negative rods producing extended-spectrum beta-lactamases (ESBLs)].

Authors
  • Yamaguchi, T
  • Kohno, S
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Apr 01, 2001
Volume
59
Issue
4
Pages
750–755
Identifiers
PMID: 11305001
Source
Medline
License
Unknown

Abstract

The prevalence of organisms producing extended-spectrum beta-lactamases(ESBLs) has been increasing all over the world. ESBLs confer resistance to cefotaxime, ceftazidime, aztreonam, extended-spectrum penicillins, and structurally related beta-lactams in clinical isolates of K. pneumoniae and E. coli. Under the influence of antimicrobial agents, bacteria that primarily produce TEM-type or SHV-type beta-lactamases developed point mutations in structural genes which served to extend the substrate specificity of the enzymes. Infections caused by ESBLs producing isolates are difficult to detect with current susceptibility tests, and are difficult to treat. This article provides an historical overview of the emergence of ESBLs carrying gram-negative rods and consider how to treat their infections.

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