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Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study

Authors
  • Zhang, Hua1
  • Du, Feng2
  • Cao, Xiao-jun1
  • Feng, Xia-long2
  • Zhang, He-ping1
  • Wu, Zheng-xia1
  • Wang, Bao-Feng1
  • Zhang, Hong-juan1
  • Liu, Rui1
  • Yang, Jian-jun2
  • Ning, Bo2
  • Chen, Kai1
  • Huang, Zhen-peng3
  • 1 Baoji Central Hospital, No. 8 Jiangtan Rd, Baoji, Shaanxi, 721008, China , Baoji (China)
  • 2 Baoji Central Hospital, Baoji, Shaanxi, 721008, China , Baoji (China)
  • 3 Present Address: Guangzhou Institute of Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No. 78 Hengzhigang, Guangzhou, Guangdong, 510095, China , Guangzhou (China)
Type
Published Article
Journal
BMC Infectious Diseases
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 24, 2021
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12879-021-05897-z
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundA large-scale global outbreak of coronavirus disease-19 (COVID-19) out of Wuhan, from China, occurred in January 2020. To examine the clinical characteristics of COVID-19 in infected patients out of Wuhan, from China.MethodsThirteen patients were confirmed to be infected with novel coronavirus-2019 (2019-nCoV) between January 27 and February 8, 2020, in Baoji city, Shannxi, northwestern China. Epidemiological and clinical information, and computed to morphology imaging data from all COVID-19 patients were collected; cases were divided into two groups according to the severity of infection (mild or severe).ResultsNine (9/13) COVID-19 patients exhibited mild disease severity, and defined as second-generation human-to-human transmission cases. Most patients (11/13) had a history of travel to or from Wuhan. There were no differences in sex and age between the mild and severe cases (all P > 0.05). A moderate degree of fever (11/13), cough (13/13), and fatigue (8/13) were common symptoms; however, there was no statistical difference between mild and severe cases in this regard (all P > 0.05). Oxyhemoglobin saturation and oxygenation index decreased, and C-reactive protein (CRP) and serum amyloid A (SAA) levels were elevated in all patients with COVID-19 infection, with statistically significant differences between those with severe disease and mild infection (all P < 0.05). Twelve of 13 COVID-19 patients exhibited changes in chest CT imaging features, and time course changes were different between mild and severe cases (all P < 0.05).ConclusionMost cases of COVID-19 infection were second-generation human-to-human transmissions from Wuhan and were mild in severity. The clinical characteristics of COVID-19 varied. Oxyhemoglobin saturation, oxygenation index, CRP and SAA levels, and CT features were reliable parameters to evaluate the severity of COVID-19 infection. However, a few patients with mild COVID-19 disease lacked typical characteristics such as fever and changes in CT imaging features.

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