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Clinical and biomarker correlates of androgen-independent, locally aggressive prostate cancer with limited metastatic potential.

Authors
  • Assikis, Vasily J
  • Do, Kim-Anh
  • Wen, Sijin
  • Wang, Xuemei
  • Cho-Vega, Jeong Hee
  • Brisbay, Shawn
  • Lopez, Remigio
  • Logothetis, Christopher J
  • Troncoso, Patricia
  • Papandreou, Christos N
  • McDonnell, Timothy J
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Oct 15, 2004
Volume
10
Issue
20
Pages
6770–6778
Identifiers
PMID: 15501953
Source
Medline
License
Unknown

Abstract

The cohort of prostate cancer patients, characterized by locally aggressive disease rather than lethal metastatic progression, was associated with a distinctive biomarker signature. The biomarker profile was, in general, more consistent with low-grade prostate cancer exhibiting local growth rather than metastatic progression. Ongoing studies will establish whether this unique subset of patients can be identified prospectively.

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