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A clinical biomarker assay for the quantification of d3-creatinine and creatinine using LC-MS/MS.

Authors
  • Leonard, Michael
  • Dunn, John
  • Smith, Glenn
Type
Published Article
Journal
Bioanalysis
Publisher
"Future Science, LTD"
Publication Date
Mar 01, 2014
Volume
6
Issue
6
Pages
745–759
Identifiers
DOI: 10.4155/bio.13.323
PMID: 24702109
Source
Medline
License
Unknown

Abstract

Novel LC-MS/MS assays were developed that quantify the biomarkers d3-creatinine, creatinine and d3-creatine in urine. This method allows the estimation of total body creatine pool size and subsequent calculation of muscle mass. This assay was originally validated as fit-for-purpose and was followed by full validation.

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