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Clinical Application of Vibration Controlled Transient Elastography in Patients with Chronic Hepatitis B.

Authors
  • Liang, Xie-Er1
  • Chen, Yong-Peng1
  • 1 State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, China. , (China)
Type
Published Article
Journal
Journal of clinical and translational hepatology
Publication Date
Dec 28, 2017
Volume
5
Issue
4
Pages
368–375
Identifiers
DOI: 10.14218/JCTH.2017.00006
PMID: 29226103
Source
Medline
Keywords
License
Unknown

Abstract

Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis B. Due to the limitation of liver biopsy, non-invasive methods, especially liver stiffness measurement (LSM) by vibration controlled transient elastography, have been developed and widely applied for liver fibrosis assessment. LSM aims to reduce, but not to substitute, the need for liver biopsy for fibrosis/cirrhosis diagnosis. While LSM may have potential utility in monitoring treatment response, its applications in prediction of liver complications in terms of portal hypertension and esophageal varices, as well as disease prognosis, have been gradually validated. Here, we review the latest clinical applications of LSM in patients with chronic hepatitis B.

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