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[A clinical analysis on the variance of bone density in patients with cirrhosis].

Authors
  • Zhang, Z Y
  • Chen, X
Type
Published Article
Journal
Zhonghua nei ke za zhi
Publication Date
Dec 01, 1994
Volume
33
Issue
12
Pages
817–820
Identifiers
PMID: 7768139
Source
Medline
License
Unknown

Abstract

In 46 patients with decompensated posthepatitis cirrhosis, various clinical manifestations resulted from changes of bone density were noted. The relation between the changes of bone density and the level of blood calcium, blood phosphorus and alkaline phosphatase (AKP) as well as the metabolism of vitamin D was studied. It is shown that: (1) Bone mineral content (BMC) in the cirrhosis group decreased as compared with that in a control group (P < 0.05). (2) Blood calcium and phosphorus level decreased, whereas AKP level increased significantly (P < 0.01) in the cirrhosis group. (3) When BMC decreased, blood calcium and phosphorus level also decreased significantly (P < 0.01). When the condition of cirrhosis deteriorated, these changes became more obvious. The reasons may be: (1) Disorder of vitamin D metabolism in cirrhosis. (2) Decrease of calcium absorption by intestine. (3) Nutritional disturbance. It is suggested that the occurrence of bone rarefaction in cirrhosis was due to multiple factors.

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