Dengue poses a huge public health threat. It places physical and financial burden on individuals affected, family, and national health systems. This descriptive study aimed for two specific objectives; to investigate the weather effects on dengue incidence and to estimate level of risk in the central region of Thailand. It utilized a 10-year population level dengue morbidity data and meteorological data from 2007 to 2016. Kriging method was used to interpolate a weighted risk factor upon a 5-point risk estimate was developed for estimating area risk on a 5-point scale. The findings showed that 2 out of 16 provinces (12.5%) are strong to very strong risk areas for dengue, including Bangkok and Nonthaburi provinces. The study revealed that the impact of La Niña and El Niño on increased dengue incidence and risk level in Bangkok. We recommend further studies to establish intersections of dengue disease and social determinants of health.