Affordable Access

deepdyve-link
Publisher Website

Climacteric symptoms are related to thyroid status in euthyroid menopausal women.

Authors
  • Slopien, R1
  • Owecki, M2
  • Slopien, A3
  • Bala, G4
  • Meczekalski, B4
  • 1 Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland. [email protected] , (Poland)
  • 2 Department of Public Health, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 3 Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 4 Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Jan 01, 2020
Volume
43
Issue
1
Pages
75–80
Identifiers
DOI: 10.1007/s40618-019-01078-7
PMID: 31392574
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Climacteric symptoms are a variety of disturbing complaints occurring during menopausal transition, many of which may be influenced by hormonal abnormalities other than related to sex steroids. In this study, we investigated the association between the intensity of climacteric symptoms measured with the Kupperman index and a thyroid status. We evaluated by measuring serum thyrotropin (TSH), and free thyroxine (fT4) 202 euthyroid women admitted to the Department of Gynecological Endocrinology, Poznan University of Medical Sciences because of climacteric symptoms. Patients were both in perimenopause (n = 74) and postmenopause (n = 128), with no history of thyroid disorders. Results presented as the mean value and standard deviation were as follows: age 54.2 ± 4.9 years, BMI 26.8 ± 4.6 kg/m2, Kupperman index 26 ± 13.1 points, TSH 2.4 ± 2.6 mU/l, fT4 1.2 ± 0.37 ng/dl. We observed a negative correlation between fT4 and the time since the last menses (R = - 0.38; p = 0.02) as well as between serum TSH concentration and sweating (R = - 0.18; p = 0.03), general weakness (R = - 0.17; p = 0.03), and palpitation (R = - 0.18; p = 0.02) and a positive correlation between fT4 and nervousness (R = 0.34; p = 0.007) and palpitations (R = 0.25; p = 0.04). In the perimenopausal subgroup, there was a positive correlation between fT4 and general weakness (R = 0.42; p = 0.03), palpitations (R = 0.50; p = 0.009), and paresthesia (R = 0.46; p = 0.01). In the postmenopausal subgroup, there was a negative correlation between TSH and sweating (R = - 0.21; p = 0.03). Menopausal symptoms are related to thyroid status in euthyroid menopausal women.

Report this publication

Statistics

Seen <100 times