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"Clicked" sugar-curcumin conjugate: modulator of amyloid-β and tau peptide aggregation at ultralow concentrations.

Authors
  • Dolai, Sukanta
  • Shi, Wei
  • Corbo, Christopher
  • Sun, Chong
  • Averick, Saadyah
  • Obeysekera, Dinali
  • Farid, Mina
  • Alonso, Alejandra
  • Banerjee, Probal
  • Raja, Krishnaswami
Type
Published Article
Journal
ACS Chemical Neuroscience
Publisher
American Chemical Society
Publication Date
Dec 21, 2011
Volume
2
Issue
12
Pages
694–699
Identifiers
DOI: 10.1021/cn200088r
PMID: 22860163
Source
Medline
Keywords
License
Unknown

Abstract

The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-β and tau peptide aggregation is presented. Curcumin inhibits amyloid-β and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Aβ and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.

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