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Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Infectivity in the Mouse Model of Lung Infection

Authors
  • Lee Ann Campbell
  • Amy Lee
  • Cho-chou Kuo
Publisher
American Society for Microbiology
Publication Date
May 01, 2006
Source
PMC
Keywords
License
Unknown

Abstract

Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.

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