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Clearance of persistent SARS-CoV-2 RNA detection in a NF kappa B-Deficient patient in association with the ingestion of human breast milk: a case report

  • Sabino, JS
  • Amorim, MR
  • De Souza, WM
  • Marega, LF
  • Mofatto, LS
  • Toledo-Teixeira, DA
  • Forato, J
  • Stabeli, RG
  • Costa, ML
  • Spilki, FR
  • Sabino, EC
  • Faria, NR
  • Benites, BD
  • Addas-Carvalho, M
  • Stucchi, RSB
  • Vasconcelos, DM
  • Weaver, SC
  • Granja, F
  • Proenca-Modena, JL
  • Vilela, MMDS
Publication Date
May 06, 2022
Spiral - Imperial College Digital Repository
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Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essential role against respiratory virus infection in mucosa cells, being, in addition, more potent in neutralizing SARS-CoV-2 than IgG, here we report the clinical course of an NFκB-deficient patient chronically infected with the SARS-CoV-2 Gamma variant, who, after a non-full effective treatment with plasma infusion, received breast milk from a vaccinated mother by oral route as treatment for COVID-19. After such treatment, the symptoms improved, and the patient was systematically tested negative for SARS-CoV-2. Thus, we hypothesize that IgA and IgG secreted antibodies present in breast milk could be useful to treat persistent SARS-CoV-2 infection in immunodeficient patients

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