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[Clear cell tumor of the lung].

Authors
  • Drebber, U
  • Ortmann, M
  • Kasper, H U
  • Kern, M A
  • Fischer, U M
  • Nemat, A T
  • Dienes, H P
Type
Published Article
Journal
Der Pathologe
Publication Date
Sep 01, 2005
Volume
26
Issue
5
Pages
378–382
Identifiers
PMID: 15735949
Source
Medline
License
Unknown

Abstract

Clear cell tumors of the lung are rare tumors composed of epithelioid HMB45 positive tumor cells. It has been proposed that clear cell tumors generate from perivascular epithelioid cells which are also found in renal angiomyolipoma. Due to its morphologic epithelioid features with clear cytoplasm the distinction from either primary or metastatic clear cell carcinoma is difficult. Usually clinical investigations do not lead to the final diagnosis so that only subsequent histological examination and immunophenotyping can establish the correct tumor classification. We describe the case of a 52 year old woman who underwent exploratory thoracotomy because of a lung mass in the right lower lobe. In frozen sections a solid trabecular tumor was diagnosed, paraffin histology and immunohistochemistry revealed a clear cell tumor of the lung. The difficulty of the correct diagnosis of the clear cell tumor of the lung in frozen sections is discussed as well as the differential diagnosis.

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