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Clara epithelial cell depletion in the lung.

Authors
  • Sonar, Sanchaita S
  • Dudda, Jan C
Type
Published Article
Journal
Methods in Molecular Biology
Publication Date
Jan 01, 2013
Volume
1032
Pages
229–234
Identifiers
DOI: 10.1007/978-1-62703-496-8_18
PMID: 23943457
Source
Medline
License
Unknown

Abstract

The bronchial epithelium has been increasingly recognized as an important immunomodulatory compartment in asthma and other lung diseases. Clara cells, which comprise the nonciliated secretory epithelial cells, are an important epithelial cell type with functions in the regulation of lung homeostasis and inflammation. Using naphthalene, Clara cells can be depleted within 24 h and regenerate by 1 month, hence, providing an easy method to study the impact of Clara cells on lung inflammation.

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