CL 64,855, a potent anti-Trypanosoma cruzi drug, is also mutagenic in the Salmonella/microsome assay.
- Published Article
Memórias do Instituto Oswaldo Cruz
- Publication Date
Jan 01, 1986
The nitroimidazole-tiadiazole derivative CL 64,855 (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole, a potent anti-trypanosomal drug, was assayed in a short-term bacterial mutagenicity test with Salmonella typhimurium strains TA 98, TA 100 and TA 102. Results indicate that CL 64,855 is a potent frameshift mutagen detected by strains TA 98 and TA 102. CL 64,855 was able to revert the indicators strains at concentrations as low as 0.1 micrograms/plate. Metabolic activation experiments with rat liver microsomal fractions did not increase the mutagenic action of CL 64,855.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3540528