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Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies

Authors
  • Conte, Elena1
  • Bresciani, Elena2
  • Rizzi, Laura2
  • Cappellari, Ornella1
  • De Luca, Annamaria1
  • Torsello, Antonio2
  • Liantonio, Antonella1
  • 1 (A.D.L.)
  • 2 (A.T.)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Feb 13, 2020
Volume
21
Issue
4
Identifiers
DOI: 10.3390/ijms21041242
PMID: 32069876
PMCID: PMC7072891
Source
PubMed Central
Keywords
License
Green

Abstract

Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, cisplatin remains the first-line therapy for several types of solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced muscle wasting are urgently needed. The dissection of the molecular pathways responsible for cisplatin-induced muscle dysfunction gives the possibility to identify novel promising therapeutic targets. In this context, the use of animal model of cisplatin-induced cachexia is very useful. Here, we report an update of the most relevant researches on the mechanisms underlying cisplatin-induced muscle wasting and on the most promising potential therapeutic options to preserve muscle mass and function.

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