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Cisplatin-based combination chemotherapy for elderly patients with non-small-cell lung cancer.

Authors
Type
Published Article
Journal
Cancer chemotherapy and pharmacology
Publication Date
Volume
40
Issue
6
Pages
469–474
Identifiers
PMID: 9332460
Source
Medline

Abstract

Elderly patients treated with mitomycin-containing regimens have higher hematologic toxicities than younger patients. The results of this study are consistent with the previously reported pharmacologic data on mitomycin suggesting altered pharmacokinetics in elderly patients. The improved response rate in the elderly patients was probably because more elderly patients had earlier disease, squamous cell carcinoma and better performance status. Cisplatin-based chemotherapy was tolerable for most elderly NSCLC patients with good performance status.

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