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Circulating tumor cells and PET.

Authors
  • Yu, Jian Q
  • Cristofanilli, Massimo
Type
Published Article
Publication Date
Oct 01, 2011
Volume
52
Issue
10
Pages
1501–1504
Identifiers
DOI: 10.2967/jnumed.111.097683
PMID: 21911596
Source
Medline
License
Unknown

Abstract

Understanding the distinct molecular features of solid tumors provides the opportunity to develop more targeted and effective therapies. The evaluation and monitoring of these therapies require sophisticated laboratory and imaging technologies to detect potential benefit not necessarily translating into significant changes in tumor size. PET has emerged as the most sensitive imaging technique for providing the metabolic profile of an individual tumor. Most recently, the detection of circulating tumor cells in the peripheral blood of patients with advanced malignancies has provided another dimension to the use of PET for sensitive therapeutic monitoring. Moreover, molecular characterization of circulating tumor cells holds promise for furthering the care of cancer patients.

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