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Circulating TFH cells as a marker for early therapeutic intervention in T1D

Authors
  • Bettelli, Estelle1, 2
  • Campbell, Daniel J.1, 2
  • 1 Benaroya Research Institute, Seattle, WA, USA , Seattle (United States)
  • 2 University of Washington School of Medicine, Seattle, WA, USA , Seattle (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Sep 01, 2020
Volume
21
Issue
10
Pages
1141–1142
Identifiers
DOI: 10.1038/s41590-020-0766-6
Source
Springer Nature
License
Yellow

Abstract

Costimulatory blockade via the CTLA-4–Ig fusion protein abatacept is beneficial in patients with early-onset type 1 diabetes, but some individuals benefit more than others. A new study reports that the pretreatment abundance of T follicular helper (TFH) cells could predict clinical responses to abatacept.

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