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Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk.

Authors
  • Wagner, Nana-Maria1
  • Brandhorst, Gunnar
  • Czepluch, Frauke
  • Lankeit, Mareike
  • Eberle, Christoph
  • Herzberg, Sebastian
  • Faustin, Vivien
  • Riggert, Joachim
  • Oellerich, Michael
  • Hasenfuss, Gerd
  • Konstantinides, Stavros
  • Schäfer, Katrin
  • 1 Department of Cardiology and Pulmonary Medicine, University Medical Center Goettingen, Goettingen, Germany. , (Germany)
Type
Published Article
Journal
Obesity
Publisher
Wiley (Blackwell Publishing)
Publication Date
Mar 01, 2013
Volume
21
Issue
3
Pages
461–468
Identifiers
DOI: 10.1002/oby.20087
PMID: 23592653
Source
Medline
License
Unknown

Abstract

Our findings thus reveal an association between circulating Treg cells and measures of adiposity, inflammation, and glucose intolerance. Although further prospective studies are needed, we present data suggesting that the determination of Treg cells might be useful to identify obese subjects at increased risk of developing cardiovascular and/or metabolic complications.

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