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Circulating miRNA-202-3p is a potential novel biomarker for diagnosis of type 1 gastric neuroendocrine neoplasms

Authors
  • Dou, Dou1, 2
  • Li, Xiao-kou1, 2
  • Xia, Qi-sheng2
  • Chen, Ying-ying1, 2
  • Li, Yuan-liang1, 2
  • Wang, Chao2
  • Qi, Zhi-rong2
  • Tan, Huang-ying2
  • 1 Beijing University of Chinese Medicine, Beijing, China , Beijing (China)
  • 2 China-Japan Friendship Hospital, Beijing, China , Beijing (China)
Type
Published Article
Journal
BMC Gastroenterology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 23, 2021
Volume
21
Issue
1
Identifiers
DOI: 10.1186/s12876-021-01769-7
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundCurrently, there are no circulating diagnostic biomarkers for gastric neuroendocrine neoplasms (g-NENs). In previous studies, we found that miRNA-202-3p is overexpressed in the tumour tissue of type 1 g-NEN. We speculated that miRNA-202-3p is also likely to be highly expressed in circulating blood.MethodsA total of 27 patients with type 1 g-NEN and 27 age- and sex-matched control participants were enrolled in this study. The miRNA-202-3p levels in serum obtained from the participants were measured by qRT‐PCR. The expression level of miRNA-202-3p in the samples was calculated by comparison with a standard curve.ResultsThe clinical characteristics of the patients were similar to those of the patient samples in previous reports. Expression of miRNA-202-3p was significantly higher in the patient group (3.84 × 107 copies/nl) than in the control group (0.635 × 107 copies/nl). The area under the ROC curve (AUC) was 0.878 (95% CI: 0.788–0.968), and the optimal cut-off point was approximately 1.12 × 107 copies/nl. The sensitivity and specificity were 88.9% and 77.8%, respectively.ConclusionThis study suggests that miRNA-202-3p is potentially useful as a biomarker of type 1 g-NEN; further investigation and verification should be performed in future research.

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