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Circulating IGF-I levels in monitoring and predicting efficacy during long-term GH treatment of GH-deficient adults.

Authors
  • Ezzat, S
  • Fear, S
  • Gaillard, R-C
  • Gayle, C
  • Marcovitz, S
  • Mattioni, T
  • Nussey, S
  • Rees, A
  • Svanberg, E
Type
Published Article
Journal
European journal of endocrinology / European Federation of Endocrine Societies
Publication Date
Dec 01, 2003
Volume
149
Issue
6
Pages
499–509
Identifiers
PMID: 14640990
Source
Medline
License
Unknown

Abstract

Improved body composition is both reflected by IGF-I changes and predicted inversely by baseline adiposity. Other effects of GH replacement on cardiac function, dyslipidaemia and quality of life, however, do not correlate with circulating IGF-I concentrations. Our findings validate the importance of sustained GH therapy, but caution on the interpretation of IGF-I levels in monitoring the long-term effects of GH treatment.

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