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Circulating endothelin-1 levels in patients with bronchial asthma.

Authors
  • Aoki, T
  • Kojima, T
  • Ono, A
  • Unishi, G
  • Yoshijima, S
  • Kameda-Hayashi, N
  • Yamamoto, C
  • Hirata, Y
  • Kobayashi, Y
Type
Published Article
Journal
Annals of allergy
Publication Date
Oct 01, 1994
Volume
73
Issue
4
Pages
365–369
Identifiers
PMID: 7944006
Source
Medline
License
Unknown

Abstract

We attempted to clarify the relationship between circulating endothelin-1 levels and bronchial hyperreactivity in asthmatic patients. Sixty-two asthmatic patients were studied for plasma endothelin-1 levels during acute asthma. The relationship between plasma endothelin-1 levels and pulmonary function (FEV1/FVC) was examined in 17 patients. Twelve patients were studied for changes in plasma endothelin-1 levels during methacholine inhalation tests. Plasma endothelin-1 levels during acute asthma correlated with the severity of acute asthma defined with the Clinical Asthma Evaluation Score, and those during the methacholine challenge test correlated with the grade of bronchoconstriction (P < .01). A significant negative correlation was observed between plasma endothelin-1 levels and FEV1/FVC ratio (P < .01). These results suggest that circulating endothelin-1 levels may reflect the severity of acute asthma.

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